Blood Pressure Medication And Cbd Oil

Does CBD help lower high blood pressure?

• In a 2017 study published in the JCI Insight Journal, researchers concluded that a single dose of CBD reduced resting blood pressure and the blood pressure response to stress^{(1 )}.
• However, researchers believed that the results were a reflection of CBD's anti-anxiety and analgesic effects^{(2 )}.
• Authors of a 2019 study published in the Brazilian Journal of Psychiatry demonstrated that CBD reduced the response to stressful environmental factors when given in the optimal dosage^{(3 )}.
• Given that most of the results from blood pressure-related studies done on CBD have been gathered through tests that involve either healthy volunteers or animals, recent research on ill human subjects is still lacking.
• The American Heart Association (AHA) says that with high blood pressure, the best prevention is knowing the blood pressure reading and making changes that matter to prevent and manage the condition^{(4 )}.

Best CBD Oils For High Blood Pressure

A sublingual application of CBD oil tincture may be the best way to take CBD for high blood pressure as it gets absorbed by the body fast, and the effects are felt for an extended period.

Here are products that are recommended to use to help with issues related to high blood pressure.

1. Editor's Pick: CBD Oil by Spruce
2. Best Organic: Full Spectrum Hemp Oil by Nuleaf Naturals
3. Best Range of CBD Oil:CBD Oil by Healthworx
4. Most Pure: Full Spectrum CBD Oil by CBDistillery
5. Best Value: Super Good Vibes CBD Oil by Sabaidee

Editor's Pick

• Overall Clinical Score 99%

• Score breakdown
• Summary

  Each bottle of the 750mg CBD oil tincture contains 25mg of CBD per dropper full. The oil is peppermint flavor to mask any unpleasant tastes related to CBD.

  Pros

  Cons

  • Mid-strength
  • Natural peppermint flavor
  • Made from 100% organic and natural ingredients

  • No other flavors
• Features

  Discount pricing available?	20% Off Coupon Code: CBDCLINICALS
  Source Source of Hemp	Kentucky, USA & North Carolina, USA
  Form	Oil Tincture
  Ingredients	Organic Hemp Seed Oil, Full Spectrum CBD Oil
  Type Type of CBD	Full Spectrum
  Extraction Extraction Method	Moonshine extraction method
  How to take it	Under tongue
  Potency Potency - CBD Per Bottle	750 mg per bottle
  Carrier Oil	Organic Hemp Seed Oil
  Concentration CBD Concentration Per Serving	25mg of CBD per dropper full (1ml)
  Drug Test	Contains 0.3% THC but there is a chance you may test positive for marijuana
  Flavours	Peppermint
  Price Range	$89 ($75.65 for subscriptions, 15% discount from regular price)
  $/mg CBD Price ($/mg)	$0.12/mg ($0.10/mg with subscription)
  Shipping Shipping/Time to delivery	2-4 business days (first class USPS)
  Lab Tests Lab Testing Transparency	Third Party Lab Tested post formulation for safety and potency, available on website
  Contaminants	Organic, Non-GMO, no pesticides, no herbicides, no solvents or chemical fertilizers, No preservatives or sweeteners
  Allergens	Vegan, Gluten free
  Refund policy	Within 30 days
  Recommended for	New CBD users
  Countries served	USA only (all 50 states)

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Best Organic

• Overall Clinical Score 99%

• Score breakdown
• Summary

  Natural remedy for various illnesses. NuLeaf Naturals' CBD oil is a whole-plant extract containing a full spectrum of naturally occurring synergistic cannabinoids and terpenes.

  Pros

  Cons

  • Pure CBD hemp
  • All natural
  • Approximately 300 drops total

  • No other flavors
• Features

  Discount pricing available?	20% Off Coupon Code: CBDCLINICALS20
  Source Source of Hemp	Colorado, USA
  Form	Oil Tincture
  Ingredients	Full Spectrum Hemp Extract, Organic Virgin Hemp Seed Oil
  Type Type of CBD	Full Spectrum CBD
  Extraction Extraction Method	CO2 Method
  How to take it	Under the tongue for approximately 30 seconds before swallowing
  Potency Potency - CBD Per Bottle	900mg per bottle
  Carrier Oil	Organic Hemp Oil
  Concentration CBD Concentration Per Serving	60mg per dropper full (1ml)
  Drug Test	Contains 0.3% THC but there is a chance you may test positive for marijuana
  Flavours	Natural
  Price Range	$99 - $434
  $/mg CBD Price ($/mg)	$0.08 - $0.13
  Shipping Shipping/Time to delivery	2-3 Days via USPS
  Lab Tests Lab Testing Transparency	Third Party Lab Tested post formulation for safety and potency, available on website
  Contaminants	No additives or preservatives, Non-GMO, NO herbicides, pesticides, or chemical fertilizers
  Allergens	Not specified
  Refund policy	Within 30 days
  Recommended for	Health-conscious persons
  Countries served	USA (all 50 states) and over 40 countries including Australia, Azerbaijan, Beliza, Bosnia & Herzegovina, Brazil, Chile, China, Croatia, Czech Republic, Estonia, France, Hong Kong, Hungary, Ireland, Israel, Japan, Latvia, Lebanon, Lithuania, Macao, Malaysia, Malta, Netherlands, New Zealand, Oman, Paraguay, Poland, Portugal, Saudi Arabia, Serbia, Singapore, South Korea, Sweden, Switzerland, United Arab Emirates, United Kingdom, Uruguay, and many more.

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Best Range of CBD Oil

Healthworx CBD Oil

Healthworx CBD Oil offers high-quality products that is sure to give you the best results.

• Overall Clinical Score 99%

• Score breakdown
• Summary

  Healthworx CBD Oil offers a range of strength and types of cbd depending on your preference. They also give you the choice of which kind of effect you want to tackle. Healthworx as a brand has an advantage since they are based in Colorado where quality CBD ingredients can be found. With that being in mind, it is sure you can receive high-quality products from the brand especially on their CBD Oil Tinctures.

  Pros

  Cons

  • Has various variations of strengths and kinds
  • Third party lab testing

  • Contains coconut oil
  • Does not ship internationally
• Features

  Discount pricing available?	Discounts are available for members of their loyalty program
  Source Source of Hemp	Colorado
  Form	Oil Tincture
  Ingredients	Organic MCT coconut oil as carrying oil, CO2 Extracted CBD from industrial hemp
  Type Type of CBD	Full-Spectrum
  Extraction Extraction Method	CO2 Extraction
  How to take it	Take up to fifteen drops twice a day or as you need orally.
  Potency Potency - CBD Per Bottle	500mg - 5000mg
  Carrier Oil	Organic Coconut Oil
  Concentration CBD Concentration Per Serving	33.33mg - 166.66mg
  Drug Test	There may be a slight chance that it will show on positive for THC on a drug test
  Flavours	Natural
  Price Range	$34.99 - $199
  $/mg CBD Price ($/mg)	$0.069 - $0.039
  Shipping Shipping/Time to delivery	All packages are shipped out within 24-48 hours after placing an order.
  Lab Tests Lab Testing Transparency	Lab test results are available on their website.
  Contaminants	Pesticide-Free
  Allergens	Non-GMO
  Refund policy	Returns are available for unused and unopened products and can only be done within 30 days from date of purchase.
  Recommended for	CBD starters
  Countries served	USA

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Most Pure

• Overall Clinical Score 99%

• Score breakdown
• Summary

  CBDistillery's Full Spectrum Oil Tinctures combine the powers of CBD oil and other naturally occurring plant proteins, minerals, vitamins, and more so that you can get all of the benefits of the cannabis plant without any potentially intoxicating effects.

  Pros

  Cons

  • 60-Day Satisfaction Guarantee
  • Various strengths
  • Oil extracted from aerial plant parts of US grown industrial hemp
  • Sourced from non-GMO industrial hemp grown in the USA through natural farming practices

  • Dropper is a bit shaky
• Features

  Discount pricing available?	CBDCLINICALS15
  Source Source of Hemp	Colorado, USA
  Form	Oil Tincture
  Ingredients	Fractionated Coconut Oil (MCT) and Full Spectrum CBD Hemp Extract (Aerial Parts)
  Type Type of CBD	Full-spectrum
  Extraction Extraction Method	CO2 extraction
  How to take it	Apply your desired dosage and hold under the tongue for 10-20 seconds before swallowing.
  Potency Potency - CBD Per Bottle	500mg - 5000mg
  Carrier Oil	Coconut Oil (MCT)
  Concentration CBD Concentration Per Serving	16.6mg to 166.6mg
  Drug Test	May contain trace amounts of hemp derived THC <0.3%
  Flavours	None
  Price Range	$35 - $240
  $/mg CBD Price ($/mg)	$0.04 - $0.07
  Shipping Shipping/Time to delivery	Standard UPS Shipping, ships up to 5 business days
  Lab Tests Lab Testing Transparency	Third Party Lab Tested post formulation for safety and potency, available on website
  Contaminants	Contaminant-free
  Allergens	Allergen-free
  Recommended for	Different CBD users with different needs

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Best Value

• Overall Clinical Score 99%

• Score breakdown
• Summary

  Super Good Vibes CBD Oil provides the purest and highest quality Cannabidiol (CBD) on the market as well as other high quality phytocannabinoids, terpenes, vitamins, omega fatty acids, trace minerals, and other beneficial for your health elements, which all work together to provide benefits.

  Pros

  Cons

  • Extra strong
  • Significant benefits with just a few drops
  • 100% Natural ingredients

  • No other flavors
• Features

  Discount pricing available?	15% Off Coupon Code: CBDCLINICALS15
  Source Source of Hemp	Colorado, USA
  Form	Oil Tincture
  Ingredients	Cannabidiol (CBD), Coconut Medium-chain triglycerides (MCT) Oil, Peppermint oil
  Type Type of CBD	Broad Spectrum
  Extraction Extraction Method	CO2-extraction
  How to take it	Using 1-3 servings per day as needed is a good start to determine how much you need
  Potency Potency - CBD Per Bottle	1000 mg per bottle
  Carrier Oil	Coconut MCT Oil
  Concentration CBD Concentration Per Serving	33.5 mg per dropper (1ml)
  Drug Test	Contains 0.3% THC but there is a chance you may test positive for marijuana
  Flavours	Peppermint
  Price Range	Single Bottle - $119.95, 2-Pack - $109.97 each, 3-Pack - $98.31 each, 6-Pack - $79.99 each
  $/mg CBD Price ($/mg)	Single bottle - $0.010, 2-Pack - $0.011, 3-Pack - $0.009, 6-Pack - $0.007
  Shipping Shipping/Time to delivery	3-5 Business days
  Lab Tests Lab Testing Transparency	Third Party Lab Tested post formulation for safety and potency, available on website
  Contaminants	Contaminant-free
  Allergens	Vegan and Gluten-free
  Refund policy	Within 30 days
  Recommended for	Patients who are looking for serious CBD oil support
  Countries served	USA only (all 50 states)

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Why People Are Taking CBD for High Blood Pressure

According to the Centers for Disease Control and Prevention (CDC), high blood pressure can harden and narrow the arteries, which decreases the flow of blood and oxygen to the heart, leading to heart disease^{(5 )} .

In a 2015 study conducted by researchers from the University of Nottingham Royal Derby Hospital in the UK, CBD was shown to be a potent vascular relaxant to human gut arteries, suggesting its potential benefits to dilate blood vessels and increase blood flow^{(6 )} .

How CBD Oil Works to Help with High Blood Pressure

CBD has been shown to possess potential benefits that may help lower blood pressure by addressing health issues that cause blood pressure to rise.

CBD's Anti-Anxiety Effects

Some factors linked to high blood pressure are anxiety and lack of sleep.

In a 2019 study published in The Permanente Journal , sleep and anxiety scores were measured in human subjects, and the findings showed that CBD could hold benefits for anxiety-related disorders^{(7 )} .

In another study , which was published in the Journal of Alternative and Complementary Medicine in 2019, CBD was shown to help in the treatment of post-traumatic stress disorder (PTSD)^{(8 )} .

The relaxation response can reduce blood pressure in people with hypertension, as indicated in the results of a study published in the Journal of Alternative and Complementary Medicine in 2018^{(9 )} .

CBD as a Vasodilator

As a natural vasodilator, CBD may help improve positive cardiovascular health by widening the blood vessels to allow smooth blood flow.

CBD's role as a vasodilator was highlighted in a double-blind, placebo-controlled, and randomized crossover study conducted by researchers from the Royal Derby Hospital Centre and Oxford Centre for Diabetes, Endocrinology & Metabolism, Churchill Hospital in the UK in 2017^{(10 )} .

In the said study , researchers explored the connection between CBD and a reduction in blood pressure, and they found that a single dose of CBD oil significantly lowered blood pressure in a small study of healthy human volunteers, both under stress and at rest.

However, the authors also noted that "there are no dedicated studies in humans to date, to our knowledge, looking at the effect of CBD on either resting cardiovascular measurement or on the responses to stress, with continuous monitoring of cardiovascular parameters."

CBD's Anti-Inflammatory Effects

Studies conducted by researchers from the University of South Carolina School of Medicine in 2009 also reveal that CBD possesses anti-inflammatory properties. Since inflammation can cause high blood pressure or vice versa, eliminating inflammation may help alleviate high blood pressure^{(11 )} .

However, inflammation may be a result of other diseases as well. Thus, leading a healthy lifestyle while using CBD oil is advised.

CBD vs. Cortisol Secretion

Cortisol, the "stress hormone," is released by the body under stress. An elevated cortisol level may cause a physical stress response in the body that could raise blood pressure.

Results from a 1993 study published in the Brazilian Journal of Medical and Biological Research suggested that CBD interferes with cortisol secretion^{(12 )} . Thus, if high blood pressure is due to elevated stress levels, CBD oil may theoretically be beneficial.

CBD and The Dynamics of Blood Flow

In a systematic review and meta-analysis published in the Frontiers in Pharmacology Journal in 2017, the authors examined the hemodynamic (blood flow) effects of CBD^{(13 )} .

The authors of the said study concluded that CBD might be used as a potential remedy for cardiovascular disorders, such as hypertension and stroke.

However, they found no evidence that CBD provides similar results under non-stressful conditions.

Much of these data were from mice, and results from human studies on the effects of CBD on hemodynamics is still limited.

CBD Interacts with Neurotransmitters

Results of a 2017 study published in the Cannabis and Cannabinoid Research Journal show how a neurotransmitter, such as anandamide, plays a critical role in the functioning of the heart^{(14 )} .

Data from the study has shown that CBD oil regulates the reuptake of essential heart neurotransmitters that control the cardiovascular system.

CBD's Neuroprotective Effects

A study published in the British Journal of Clinical Pharmacology in 2013 has shown how CBD allows blood flow in the vessels to maintain healthy blood pressur e in animal models ^{(15 )} .

The review has also presented evidence of the positive effects of CBD in the cardiovascular system.

Data from the said study illustrate that CBD potentially provides neuroprotective effects, which may help protect the brain against stroke.

The findings also suggest that CBD can induce a healthy heart rhythm after an ischemic attack, which is caused by a build-up or blockage in the arteries. Thus, CBD was shown to potentially improve heart performance immediately after a heart attack in non-human models.

Although the results demonstrate that the cardiovascular system is a valid therapeutic target for CBD, the target sites of action for CBD remain to be established for most of the responses.

As more and more studies and clinical trials are conducted in human subjects, CBD oil's efficacy in treating high blood pressure would become more explicit.

The Pros and Cons of CBD Oil for High Blood Pressure

The Pros

• CBD "is generally well tolerated with a good safety profile," as the World Health Organization (WHO) states in a critical review^{(16 )} .
• CBD's feasibility as a potential remedy to hypertension-related symptoms has been shown in the numerous studies stated above.

The Cons

• Studies are too limited to determine whether or not CBD is an effective treatment for conditions other than the ones approved by the U.S. Food and Drug Administration (FDA).
• As with the use of any natural chemical compound, there are risks involved in using CBD. According to the Mayo Clinic, possible side effects include drowsiness, dry mouth, diarrhea, fatigue, and reduced appetite^{(17 )} .
• Most of the results from blood pressure-related studies done on CBD have been gathered through tests that involve healthy volunteers, very low population sizes, or animals, like that of a study done on rats^{(18 )} .

Given the limited scope, facts cannot be established that the results of previous investigations would be comparable with that of tests involving ill human subjects.

• CBD has been shown to alter how the body metabolizes certain medications, as a 2017 research reveals^{(19 )} . With results published in the Cannabis and Cannabinoid Research Journal , the research suggests that the combination of CBD with other high blood pressure medications has the potential to alter the blood concentrations of either substance.

Results of a study published in the Medicines Journal indicated that the CYP450 family of enzymes is responsible for metabolizing several phytocannabinoids (cannabinoids that exist naturally in the cannabis plant), including CBD ^{(20 )} .

If one is already on high blood pressure medication, taking CBD in combination with the prescribed drug can lower blood pressure too much. Blood pressure that is too low is as bad as blood pressure that is too high.

• The lack of regulation makes it difficult to determine whether the CBD gummies, tinctures, patches, balms, and gelcaps contain what the product label claims.

A 2017 review published in the Journal of the American Medical Association revealed labeling inaccuracies among CBD products. Some products had less CBD than stated, while others had more^{(21 )} .

Experts recommend speaking with a physician before adding CBD onto the medications that are currently taken. The doctor may want to reduce the dosage strength of the blood pressure prescription before incorporating CBD oil into the daily regimen of an individual.

How CBD Oil Compares to Alternative Treatments for High Blood Pressure

Although the prescription medications currently available for hypertension are effective, they bring about side effects, which can make the treatment an unpleasant experience.

Cannabidiol (CBD), on the other hand, is a natural alternative that has shown to have little side effects, and the side effects of CBD are less common than the effects associated with most pharmaceutical medications used to treat high blood pressure.

How To Choose The Right CBD for High Blood Pressure

The best CBD oil product to use for high blood pressure is CBD tincture. By taking a sublingual dosage, the optimum level of CBD gets absorbed into the system, which means CBD works the fastest, and the effects are probably felt the longest.

However, regardless of the form of CBD product one chooses, he or she must employ careful consideration in choosing the best CBD oil for high blood pressure that is right for him or her.

The following factors are essential to ensure the safety and reliability of the CBD products purchased:

1. Research on the exact legal stipulations applicable to CBD in the area where it would be purchased and used.
2. Purchase only from legitimate and reliable big brands. The majority of companies that manufacture the best CBD oil products grow their hemp from their farm, or they purchase from licensed hemp producers.
3. When buying from an online store, do some research on product reviews first. When buying from a physical store or dispensary, check whether the store is authorized by the government to sell CBD.
4. One important thing to look for in CBD products is certification codes. Several certification authorities approve certain products only after some thorough screening tests.
5. Compare company claims about their products' potency with that of the third-party lab reports.
6. Consulting with a trusted medical professional who is experienced in CBD use is ideal before purchasing any CBD product .

CBD Dosage For High Blood Pressure

In a 2019 review, Mayo Clinic suggests CBD dosages based on publications, scientific research, traditional use, and expert opinion^{(22 )} .

The doses and duration of treatment depend primarily on the illness. However, there is no specific dose recommended for high blood pressure.

Results of a 2017 study published in the Cannabis and Cannabinoid Research Journal provided evidence that a dosage of up to 1,500 mg of CBD a day is well-tolerated by humans^{(23 )} .

The authors of the study also found that at lower doses, CBD showed physiological effects that could potentially help promote and maintain health, including antioxidative, anti-inflammatory, and neuroprotection effects.

Following the dosing instructions on the CBD product of choice and starting with a low dose are the best course of action for those who would like to try CBD. Taking high doses at the beginning may bring about adverse reactions in the user.

As with any medication, the dose would depend on the metabolism, genetics, size, and body weight of a person.

How to Take CBD Oil for High Blood Pressure

There are various ways to consume CBD oil, and the delivery format would most likely depend on personal preferences and lifestyle.

CBD Oil Capsules and Edibles

CBD oil capsules and edibles, such as brownies, gummies, and lozenges, are a convenient and straightforward way to take CBD oil, especially for beginners.

This format is easy to work into a routine, and the dose is consistent. Depending on the metabolism of an individual, the effects can last between 6 and 12 hours. Thus, one dose is probably all that is needed during the day.

However, consuming CBD oil can delay its effects as it has to pass through the digestive system before it gets absorbed into the bloodstream. Given that the effects of the CBD oil could take at least 20 minutes to an hour to appear, CBD oil capsules and edibles do not provide immediate relief.

CBD Oil Tinctures or Drops

CBD oil tinctures or drops are a practical option for those who seek faster results and maximum dosage control.

Tinctures and drops are administered under the tongue, through which the CBD oil is absorbed directly into the bloodstream.

Place the desired quantity of drops under the tongue using a dropper, and then let the CBD oil stay in place for at least 60 seconds. Once 60 seconds have passed, swallow the CBD oil.

Sublingual application allows for results to be experienced within 30 to 60 minutes after its use, and the effects can be felt for 4 to 6 hours.

Since tinctures and drops are convenient and easy to store and travel with, they can be effortlessly administered when needed.

However, one significant drawback to CBD oil tinctures and drops is the taste, as not everyone appreciates the natural, earthy, and sometimes bitter flavor of hemp.

Although some products come in various flavors to compensate for the unpleasant taste, the addition of sugar and chemicals may be something that one wants to avoid.

CBD Oil Vapes

CBD oil vapes are one of the accelerated ways to get CBD into the body since it enters the bloodstream through the lungs, without going through the digestive system.

When vaping CBD oil, effects can be felt in minutes. However, the effects last only for 30 minutes to an hour or two.

Also, with vaping, it is difficult to determine precisely how much CBD is in each draw. Although labels for CBD oil vape products usually indicate the amount per inhale, the amount may vary in individuals. Thus, getting the dose right requires a bit of experimentation at first.

Understanding High Blood Pressure

Blood pressure is influenced by how much blood the heart pumps, how hard it pumps, and the resistance to blood flow in the arteries.

According to Mayo Clinic, the higher the amount of blood the heart pumps and the narrower the arteries, the higher the blood pressure^{(24 )} .

The narrowing and blocking of blood vessels that is caused by high blood pressure, or hypertension, affects heart health by increasing the risk of developing heart failure.

What A Blood Pressure Reading Means

When the doctor measures blood pressure, the reading is given in two numbers. The first number, referred to as systolic blood pressure, is the pressure caused by the heart contracting and releasing blood. The second number, called diastolic blood pressure, is the pressure when the heart relaxes and fills with blood.

The blood pressure reading is given as the systolic blood pressure number over the diastolic blood pressure number, such as 135/70.

A normal blood pressure reading for adults is 120/80, according to the American Heart Association (AHA)^{(25 )} .

Are There High Blood Pressure Symptoms?

The American Heart Association (AHA) calls high blood pressure a "silent killer." An individual can have high blood pressure for years without any indications^{(26 )} .

Most people with high blood pressure do not exhibit symptoms, even though blood pressure readings rise to critically-high levels.

Meanwhile, AHA says, some people with high blood pressure may experience shortness of breath, headaches, or nosebleeds. However, these symptoms are not specific and do not occur until high blood pressure has reached a life-threatening stage.

Still, even in the absence of symptoms, damage to the heart and blood vessels continues and can be detected, AHA says .

The agency warns that undetected or unregulated high blood pressure intensifies the risk of severe health problems, including strokes and heart attacks^{(27 )} .

High blood pressure typically develops over several years, and it eventually affects almost everyone^{(28 )}.

The National Institute on Aging (NIA) states that high blood pressure is a critical health issue that is typical among older people^{(29 )} .

Fortunately, it is not difficult to detect high blood pressure. One can work with a doctor to control the condition once diagnosed.

To learn more about the studies on blood pressure, go to ClinicalTrials.gov or PubMed.gov ^{(30 )} .

Traditional Medications for High Blood Pressure

Doctors often prescribe one or more of the following pharmaceutical drugs to people dealing with high blood pressure^{(31 )} :

• Diuretics, like Diuril and Lozol, increase urination which reduces sodium and fluid in the body. Because diuretics lower blood volume, they help lower blood pressure. However, one side effect of diuretics can be a loss of potassium, which is needed for proper muscular movement.
• Angiotensin II receptor blockers (ARBs) like Diovan, which, as vasodilators, dilate blood vessels. Their potential side effects include skin rashes, swelling mouth, joint and back pain, flu-like symptoms, nausea, headaches, and diarrhea.
• Metoprolol beta-blockers, like Toprol-XL and Lopressor, slow the heart rate. However, they can cause diarrhea, constipation, vomiting, fatigue, anxiety, depression, insomnia, shortness of breath, and decreased libido.
• Angiotensin-converting enzyme (ACE) inhibitors like Vasoctec and Benazepril prevent the contraction of blood vessels. Some adverse side effects may include skin rash, swelling mouth, dry cough, headaches, dizziness, and diarrhea.

According to an article published in MedlinePlus by the U.S. National Library of Medicine, high blood pressure medicines may cause some common side effects, such as diarrhea or constipation, dizziness, erection problems, fatigue, nausea or vomiting, skin rash, and weight loss or gain without trying^{(32 )} .

Sometimes, a person may need to take more than one type of drug to manage blood pressure.

Although a single drug would often be used initially, two drugs could be started for stage 2 high blood pressure.

The AHA describes stage 2 hypertension as the stage when blood pressure consistently ranges at 140/90 mm Hg or higher^{(33 )} .

People taking medications for hypertension are also warned that mixing beta-blockers and angiotensin II receptor antagonists must only be done at the recommendation of a physician since the combination can lead to acute renal failure, as a 2013 study published in the Hypertension Research Journal suggests^{(34 )} .

Lifestyle Changes to Help Prevent High Blood Pressure

Using medications as prescribed and making lifestyle changes can enhance the quality of life and reduce the risk of hypertension, says the American Heart Association (AHA)^{(35 )} . These changes include:

• Eating a healthy diet that is low in fat, cholesterol, and salt to prevent further plaque build-up in the arteries.
• Exercising regularly to strengthen your heart. This activity could be something as simple as taking a 30-minute walk each day.
• Engaging in activities that help manage stress, such as meditation, journaling, making art, and seeing a therapist.

What to Know About CBD Oil

CBD oil contains CBD , or cannabidiol , as its primary active ingredient. Cannabidiol is associated with the previously mentioned benefits, including controlling blood pressure.

Comparing CBD and THC

CBD comes from cannabis and is naturally found in hemp plants. CBD is one of more than 100 cannabinoids that occur naturally within the plant. This compound is also commonly used to produce CBD hemp oil supplements.

Hemp seed oil is produced by extracting the oil from the seeds of the hemp plant itself. This oil is abundant in nutrients, such as omega-3 and omega-6 fatty acids, making it ideal for digestion. Although some people refer to "hemp extract" as hemp oil, the term "hemp oil" is synonymous with the term "hemp seed oil."

Chemical compounds in cannabis, called cannabinoids, have shown various potential benefits by activating the body's endocannabinoid system (ECS), which is involved in regulating a variety of functions including sleep, appetite, pain and immune system response^{(36 )} .

The body produces endocannabinoids, which are neurotransmitters that bind to cannabinoid receptors in the nervous system.

The medicinal efficacy of cannabis can be optimized by incorporating the various cannabinoids, flavonoids, and terpenes that are intrinsic components of cannabis plants.

CBD is non-psychoactive, contrasting with THC (tetrahydrocannabinol), another primary cannabinoid. THC is the most significant factor contributing to the high associated with using cannabis.

Consuming CBD without any THC does not produce those effects, which means that nearly everyone should be able to function as they usually do when taking CBD.

The lack of high allows users to continue with work, school, and other commitments without a decrease in performance. It also makes CBD oil safe to take , even for those who must pass regular or random drug tests.

CBD oil must not contain any THC for CBD to be non-psychoactive. Products containing CBD isolates do not have THC, while full-spectrum CBD products do.

Any product that one buys should also state the percentage of THC, information which one can also get from its certificate of analysis.

Other Health Benefits of CBD Oil

Here are some of the more critical benefits associated with cannabidiol .

Treating Seizures

CBD can help treat some of the worst types of seizure disorders that exist, including Lennox-Gastaut syndrome and Dravet syndrome, both of which affect children and do not typically respond to traditional medications for treating seizures ^{(37 )} .

Even the U.S. Food and Drug Administration (FDA) recognizes the ability of CBD to treat seizure disorders^{(38 )} . The first cannabis-derived medication it approved is Epidiolex, which treats these conditions. That medication contains CBD.

Treating Anxiety Disorders and Depression

Those who suffer from anxiety may experience relief with CBD. Results from a 2019 study published in the Brazilian Journal of Psychiatry showed CBD's anxiolytic effect on public speaking, and there is plenty of anecdotal evidence^{(39 )} .

In another study , which was published in the Journal of the American College of Cardiology , CBD was shown to attenuate oxidative stress, as well as cardiac dysfunction, fibrosis, and cell death in a mouse model ^{(40 )} .

Treating Pain

One of the most popular uses of CBD oil is its ability to reduce chronic pain . Animal studies, like the study published in the European Journal of Pain in 2016, show that topically applied CBD may theoretically help provide pain relief and reduce inflammation from arthritis^{(41 )} .

In another study published in the Journal of Experimental Medicine , CBD was shown to reduce neuropathic pain^{(42 )} . This finding is crucial as it is one of the hardest types of pain to treat.

Some countries approve oral sprays like Sativex, which contains both CBD and THC^{(43 )} . This spray effectively treats the pain associated with multiple sclerosis (MS), a potentially disabling disease of the brain and spinal cord (central nervous system).

However, as Sativex and certain medications may trigger a drug interaction, experts advise consulting with a doctor first about all the prescription, over-the-counter (non-prescription), and herbal medications that are being taken before starting to use Sativex oral spray.

Protecting the Brain

CBD research , conducted on animal models and humans and published in the Surgical Neurology International in 2018, has shown numerous therapeutic properties for brain function and protection, both by its effect on the endocannabinoid system directly and by influencing endogenous cannabinoids^{(44 )} .

Researchers in a study published in the Journal of Psychopharmacology noted a possible effect of CBD in improving the quality of life in patients with Parkinson's disease without adverse outcomes^{(45 )} .

Studies analyzed in a 2017 review conducted by experts from the Western Sydney University in Australia also provided proof of principle for the therapeutic benefits that CBD and possibly CBD-THC combinations may provide^{(46 )} .

Data suggest that these combinations may help with the therapy of Alzheimer's disease (named after Dr. Alois Alzheimer, who noted the symptoms in 1906).

May Help Fight Cancer

A 2010 study published by the American Association for Cancer Research showed a CBD-induced cell death of breast cancer cells, suggesting that the use of CBD oil may also suppress tumor growth^{(47 )} .

Research on cannabinoids published in the Future Medicinal Chemistry demonstrates that cannabinoids may also prove beneficial in certain types of cancers that are activated by chronic inflammation^{(48 )} .

In such instances, cannabinoids, as anti-inflammatory agents, can either directly prevent tumor growth or suppress inflammation .

Meanwhile, in-depth research on CBD yields mixed results.

In a recent study published in the Bosnian Journal of Basic Medical Sciences , researchers recognized the antitumor effects of cannabinoids in various cancer types^{(49 )} .

However, these antitumor effects of cannabinoids have to prevail over their known immunosuppressive effects, which can potentially promote the production or formation of tumors.

Recent studies are still limited when it comes to CBD and cancer prevention. Longitudinal studies of humans using specific CBD products, controlling for frequency of use and dosing are needed.

Overcoming Substance Abuse

There is some evidence that using CBD may help those with addiction overcome their substance abuse.

Published in the Journal of Substance Abuse Treatment , results from a 2015 study conducted on animal models showed CBD reduced heroin-seeking behavior and reduced morphine dependence^{(50 )} .

The Legality of CBD Oil

The Cannabis sativa plant produces both hemp and marijuana. The difference between the two plants is the percentage of THC that they contain.

A cannabis plant that has 0.3 percent or less of THC content classifies as hemp, while a cannabis plant containing over 0.3 percent of THC is considered marijuana.

In the United States, cannabis-related laws are continually changing. Since marijuana and THC are on the list of controlled substances, they are currently prohibited under federal law^{(51 )} .

Meanwhile, confusion arises due to regulations that vary depending on whether the CBD is hemp-derived or extracted from marijuana. The former is legal at the federal level, while the latter is not.

Many states and Washington, D.C. have passed cannabis-related laws, making medical marijuana with high levels of THC legal. Still, marijuana may require a prescription from a licensed physician^{(52 )} .

Also, several states have made recreational use of marijuana and THC legal. One should be able to buy CBD in states where marijuana is legal for recreational or medical purposes.

NORML has information regarding state laws and penalties. ^{(53 )} .

Individuals who possess cannabis-related products in a state where they are illegal or do not have a medical prescription in states where the products are legal for medical treatment could face legal penalties.

For a complete list of legal medical marijuana states and D.C., including the corresponding laws, fees, and possession limits, visit ProCon.org ^{(54 )} .

Conclusion

According to the Centers for Disease Control and Prevention (CDC), about 75 million American adults, or 1 in 3 adults, have high blood pressure^{(55 )} . People with high blood pressure have a greater risk of heart disease and stroke, the leading causes of death in the United States.

CBD oil has shown to be a natural remedy to issues that could be linked to high blood pressure, such as stress and p a in⁽⁵⁶⁾.

Meanwhile, using medications as prescribed and making lifestyle changes can enhance the quality of life and reduce the risk of hypertension, says the American Heart Association (AHA)^{(57 )} .

Still, before experimenting with different CBD products and dosages, speak to a doctor about a CBD treatment or using CBD oil for treating high blood pressure.

For anyone still looking for more information on CBD as a medical supplement, speaking with a cannabis doctor who specializes in the subject is the best course of action.

There is a wide range of products to choose from for those who are ready to decide which product and how they would like to take CBD oil to either address medical conditions or maintain general well-being.

---

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23. Iffland K, Grotenhermen F. An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies. Cannabis Cannabinoid Res. 2017;2(1):139–154. Published 2017 Jun 1. doi:10.1089/can.2016.0034. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569602/

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26. American Heart Association. What are the Symptoms of High Blood Pressure? https://www.heart.org/en/health-topics/high-blood-pressure/why-high-blood-pressure-is-a-silent-killer/what-are-the-symptoms-of-high-blood-pressure .

27. American Heart Association. Health Threats From High Blood Pressure. https://www.heart.org/en/health-topics/high-blood-pressure/health-threats-from-high-blood-pressure .

28. Mayo Clinic, op. cit.

29. National Institute on Aging. (2018, May 2).High Blood Pressure. Retrieved from https://www.nia.nih.gov/health/high-blood-pressure .

30. ClinicalTrials.gov. Retrieved from https://clinicaltrials.gov/ct2/results?term=high+blood+pressure&Search=Search ; PubMed.gov. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/ .

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32. MedlinePlus, U.S. National Library of Medicine. High blood pressure medicines. Retrieved from https://medlineplus.gov/ency/article/007484.htm .

33. American Heart Association, op.cit.

34. Ptinopoulou, A., Pikilidou, M. & Lasaridis, A. The effect of antihypertensive drugs on chronic kidney disease: a comprehensive review. Hypertens Res 36, 91–101 (2013). https://doi.org/10.1038/hr.2012.157 .

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36. Mouslech Z, Valla V. Endocannabinoid system: An overview of its potential in current medical practice. Neuro Endocrinol Lett. 2009;30(2):153-79.

37. U.S. Food and Drug Administration (FDA). (2018, June 25). FDA approves first drug comprised of an active ingredient derived from marijuana to treat rare, severe forms of epilepsy. Retrieved from https://www.fda.gov/news-events/press-announcements/fda-approves-first-drug-comprised-active-ingredient-derived-marijuana-treat-rare-severe-forms .

38. ibid.

39. Linares IM, op. cit. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781714/

40. Rajesh M, Mukhopadhyay P, Bátkai S, et al. Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy. J Am Coll Cardiol. 2010;56(25):2115–2125. doi:10.1016/j.jacc.2010.07.033. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026637/

41. Hammell DC, Zhang LP, Ma F, et al. Transdermal cannabidiol reduces inflammation and pain-related behaviours in a rat model of arthritis. Eur J Pain. 2016;20(6):936–948. doi:10.1002/ejp.818. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851925/

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47. Ashutosh Shrivastava, Paula M. Kuzontkoski, Jerome E. Groopman and Anil Prasad. Cannabidiol Induces Programmed Cell Death in Breast Cancer Cells by Coordinating the Cross-talk between Apoptosis and Autophagy. DOI: 10.1158/1535-7163.MCT-10-1100 Published July 2011. https://mct.aacrjournals.org/content/10/7/1161.long

48. Nagarkatti P, Pandey R, Rieder SA, Hegde VL, Nagarkatti M. Cannabinoids as novel anti-inflammatory drugs. Future Med Chem. 2009;1(7):1333–1349. doi:10.4155/fmc.09.93. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828614/

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51. U.S. Food and Drug Administration (FDA). (2020, Jan 15). FDA Regulation of Cannabis and Cannabis-Derived Products, Including Cannabidiol (CBD). Retrieved from https://www.fda.gov/news-events/public-health-focus/fda-regulation-cannabis-and-cannabis-derived-products-including-cannabidiol-cbd .

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53. State Laws. Retrieved from https://norml.org/laws .

54. ProCon.org, op. Cit.

55. Centers for Disease Control and Prevention (CDC). (2020, Jan 28). High Blood Pressure. Retrieved from https://www.cdc.gov/bloodpressure/facts.htm .

56. Linares IM, op cit.; Xiong W, op. cit. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781714/

57. American Heart Association, op. cit.

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